LymphedemaV1, Main, Exploration, bibRecord, 001934

Quantitative Contrast-Enhanced Magnetic Resonance Lymphangiography of the Upper Limbs in Breast Cancer Related Lymphedema: An Exploratory Study

Identifieur interne : 001934 ( Main/Exploration ); précédent : 001933; suivant : 001935

Quantitative Contrast-Enhanced Magnetic Resonance Lymphangiography of the Upper Limbs in Breast Cancer Related Lymphedema: An Exploratory Study

Auteurs : Marco Borri ; Maria A. Schmidt ; Kristiana D. Gordon ; Toni A. Wallace ; Julie C. Hughes ; Erica D. Scurr ; Dow-Mu Koh ; Martin O. Leach ; Peter S. Mortimer

Source :

Lymphatic Research and Biology [ 1539-6851 ] ; 2015.

RBID : PMC:4492592

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Amélioration d'image, Angiographie par résonance magnétique, Femelle, Humains, Lymphoedème (diagnostic), Lymphoedème (étiologie), Lymphographie (), Membre supérieur (anatomopathologie), Produits de contraste, Traitement d'image par ordinateur, Tumeurs du sein (), Vaisseaux lymphatiques (anatomopathologie).
MESH :
- anatomopathologie : Membre supérieur, Vaisseaux lymphatiques.
- diagnostic : Lymphoedème.
- étiologie : Lymphoedème.
- Adulte d'âge moyen, Amélioration d'image, Angiographie par résonance magnétique, Femelle, Humains, Lymphographie, Produits de contraste, Traitement d'image par ordinateur, Tumeurs du sein.

English descriptors

KwdEn :
- Breast Neoplasms (complications), Contrast Media, Female, Humans, Image Enhancement, Image Processing, Computer-Assisted, Lymphatic Vessels (pathology), Lymphedema (diagnosis), Lymphedema (etiology), Lymphography (methods), Magnetic Resonance Angiography, Middle Aged, Upper Extremity (pathology).
MESH :
- chemical : Contrast Media.
- complications : Breast Neoplasms.
- diagnosis : Lymphedema.
- etiology : Lymphedema.
- methods : Lymphography.
- pathology : Lymphatic Vessels, Upper Extremity.
- Female, Humans, Image Enhancement, Image Processing, Computer-Assisted, Magnetic Resonance Angiography, Middle Aged.

Abstract

Background: Contrast-Enhanced Magnetic Resonance Lymphangiography (CE-MRL) presents some limitations: (i) it does not quantify lymphatic functionality; and (ii) enhancement of vascular structures may confound image interpretation. Furthermore, although CE-MRL is well described in the published literature for the lower limbs, there is a paucity of data with regards to its use in the upper limbs. In this proof-of-principle study, we propose a new protocol to perform CE-MRL in the upper limbs of patients with breast cancer-related lymphedema (BCRL) which addresses these limitations.

Methods and Results: CE-MRL was performed using a previously published (morphological) protocol and the proposed protocol (quantitative) on both the ipsilateral (abnormal) and contralateral (normal) arms of patients with BCRL. The quantitative protocol employs contrast agent (CA) intradermal injections at a lower concentration to prevent T2*-related signal decay. Both protocols provided high-resolution three-dimensional images of upper limb lymphatic vessels. CA uptake curves were utilized to distinguish between lymphatic vessels and vascular structures. The quantitative protocol minimized venous enhancement and avoided spurious delays in lymphatic enhancement due to short T2* values, enabling correct CA uptake characterization. The quantitative protocol was therefore employed to measure the lymphatic fluid velocity, which demonstrated functional differences between abnormal and normal arms. The velocity values were in agreement with previously reported lymphoscintigraphy and near infra-red lymphangiography measurements.

Conclusions: This work demonstrated the feasibility of CE-MRL of the upper limbs in patients with BRCL, introducing an advanced imaging and analysis protocol suitable for anatomical and functional study of the lymphatic system.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492592

DOI: 10.1089/lrb.2014.0039
PubMed: 25774851
PubMed Central: 4492592

Affiliations:

Le document en format XML

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<term>Contrast Media</term>
<term>Female</term>
<term>Humans</term>
<term>Image Enhancement</term>
<term>Image Processing, Computer-Assisted</term>
<term>Lymphatic Vessels (pathology)</term>
<term>Lymphedema (diagnosis)</term>
<term>Lymphedema (etiology)</term>
<term>Lymphography (methods)</term>
<term>Magnetic Resonance Angiography</term>
<term>Middle Aged</term>
<term>Upper Extremity (pathology)</term>
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<term>Amélioration d'image</term>
<term>Angiographie par résonance magnétique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphoedème (diagnostic)</term>
<term>Lymphoedème (étiologie)</term>
<term>Lymphographie ()</term>
<term>Membre supérieur (anatomopathologie)</term>
<term>Produits de contraste</term>
<term>Traitement d'image par ordinateur</term>
<term>Tumeurs du sein ()</term>
<term>Vaisseaux lymphatiques (anatomopathologie)</term>
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<term>Vaisseaux lymphatiques</term>
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<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphoedème</term>
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<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term>
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<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Lymphography</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lymphatic Vessels</term>
<term>Upper Extremity</term>
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<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term>
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<term>Humans</term>
<term>Image Enhancement</term>
<term>Image Processing, Computer-Assisted</term>
<term>Magnetic Resonance Angiography</term>
<term>Middle Aged</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Amélioration d'image</term>
<term>Angiographie par résonance magnétique</term>
<term>Femelle</term>
<term>Humains</term>
<term>Lymphographie</term>
<term>Produits de contraste</term>
<term>Traitement d'image par ordinateur</term>
<term>Tumeurs du sein</term>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold><italic>Background:</italic>
</bold>
 Contrast-Enhanced Magnetic Resonance Lymphangiography (CE-MRL) presents some limitations: (i) it does not quantify lymphatic functionality; and (ii) enhancement of vascular structures may confound image interpretation. Furthermore, although CE-MRL is well described in the published literature for the lower limbs, there is a paucity of data with regards to its use in the upper limbs. In this proof-of-principle study, we propose a new protocol to perform CE-MRL in the upper limbs of patients with breast cancer-related lymphedema (BCRL) which addresses these limitations.</p>
<p><bold><italic>Methods and Results:</italic>
</bold>
 CE-MRL was performed using a previously published (<italic>morphological</italic>
) protocol and the proposed protocol (<italic>quantitative</italic>
) on both the ipsilateral (abnormal) and contralateral (normal) arms of patients with BCRL. The quantitative protocol employs contrast agent (CA) intradermal injections at a lower concentration to prevent T2*-related signal decay. Both protocols provided high-resolution three-dimensional images of upper limb lymphatic vessels. CA uptake curves were utilized to distinguish between lymphatic vessels and vascular structures. The quantitative protocol minimized venous enhancement and avoided spurious delays in lymphatic enhancement due to short T2* values, enabling correct CA uptake characterization. The quantitative protocol was therefore employed to measure the lymphatic fluid velocity, which demonstrated functional differences between abnormal and normal arms. The velocity values were in agreement with previously reported lymphoscintigraphy and near infra-red lymphangiography measurements.</p>
<p><bold><italic>Conclusions:</italic>
</bold>
 This work demonstrated the feasibility of CE-MRL of the upper limbs in patients with BRCL, introducing an advanced imaging and analysis protocol suitable for anatomical and functional study of the lymphatic system.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Monleon, S" uniqKey="Monleon S">S Monleon</name>
</author>
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<biblStruct><analytic><author><name sortKey="Disipio, T" uniqKey="Disipio T">T DiSipio</name>
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<biblStruct><analytic><author><name sortKey="Witte, Cl" uniqKey="Witte C">CL Witte</name>
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<biblStruct><analytic><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T Yamamoto</name>
</author>
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<biblStruct><analytic><author><name sortKey="Lohrmann, C" uniqKey="Lohrmann C">C Lohrmann</name>
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<biblStruct><analytic><author><name sortKey="Liu, N F" uniqKey="Liu N">N-F Liu</name>
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<biblStruct><analytic><author><name sortKey="D Arcy, Ja" uniqKey="D Arcy J">JA D’ Arcy</name>
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<biblStruct><analytic><author><name sortKey="Thevenaz, P" uniqKey="Thevenaz P">P Thévenaz</name>
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<biblStruct><analytic><author><name sortKey="Moate, Pj" uniqKey="Moate P">PJ Moate</name>
</author>
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<biblStruct><analytic><author><name sortKey="Loo, Bw" uniqKey="Loo B">BW Loo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Modi, S" uniqKey="Modi S">S Modi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brorson, H" uniqKey="Brorson H">H Brorson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, Dw" uniqKey="Chang D">DW Chang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levick, Jr" uniqKey="Levick J">JR Levick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Leva, P" uniqKey="De Leva P">P De Leva</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bernstein, Ma" uniqKey="Bernstein M">MA Bernstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rohrer, M" uniqKey="Rohrer M">M Rohrer</name>
</author>
</analytic>
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<tree><noCountry><name sortKey="Borri, Marco" sort="Borri, Marco" uniqKey="Borri M" first="Marco" last="Borri">Marco Borri</name>
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<name sortKey="Hughes, Julie C" sort="Hughes, Julie C" uniqKey="Hughes J" first="Julie C." last="Hughes">Julie C. Hughes</name>
<name sortKey="Koh, Dow Mu" sort="Koh, Dow Mu" uniqKey="Koh D" first="Dow-Mu" last="Koh">Dow-Mu Koh</name>
<name sortKey="Leach, Martin O" sort="Leach, Martin O" uniqKey="Leach M" first="Martin O." last="Leach">Martin O. Leach</name>
<name sortKey="Mortimer, Peter S" sort="Mortimer, Peter S" uniqKey="Mortimer P" first="Peter S." last="Mortimer">Peter S. Mortimer</name>
<name sortKey="Schmidt, Maria A" sort="Schmidt, Maria A" uniqKey="Schmidt M" first="Maria A." last="Schmidt">Maria A. Schmidt</name>
<name sortKey="Scurr, Erica D" sort="Scurr, Erica D" uniqKey="Scurr E" first="Erica D." last="Scurr">Erica D. Scurr</name>
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Serveur d'exploration sur le lymphœdème

Quantitative Contrast-Enhanced Magnetic Resonance Lymphangiography of the Upper Limbs in Breast Cancer Related Lymphedema: An Exploratory Study

Quantitative Contrast-Enhanced Magnetic Resonance Lymphangiography of the Upper Limbs in Breast Cancer Related Lymphedema: An Exploratory Study

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur le lymphœdème
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